Every year, countless individuals are diagnosed with cancer, with radiation therapy being one of the most common treatment options. Initially, patients undergo CT-simulation, which provides critical anatomical information about the tumour and surrounding organs. Based on these CT images, treatment plans are created for the linear accelerator to target and …

Type 2 diabetes mellitus (T2DM) is a growing global health concern. The International Diabetes Federation (2025) estimates that 589 million people will be living with diabetes by 2025, largely due to unhealthy dietary patterns, physical inactivity, and rising obesity rates1. As a result, healthcare systems face increasing challenges in managing …

This research focuses on improving soft neural probes that can be safely implanted into the brain. These probes are designed to be both flexible and strong enough to avoid bending or breaking during surgery. One of their promising applications is in optogenetics, a technique that uses light to control specific …

Proteins are fundamental to the health and functioning of all living organisms. Protein modifications, which involve the addition or removal of chemical functional groups to proteins, alter protein conformations and often change protein functions. This research introduces a computational framework to evaluate how much more or less likely certain parts …

Ovarian cancer is a global health concern, affecting over 300 000 women worldwide in 2022. Despite initial success of first-line treatments, about 80% of patients with advanced-stage ovarian cancer experience recurrence, resulting in a five-year survival rate of only 46%. This high relapse rate underlines the need for new therapeutic …

Marfan syndrome is a genetic disorder that affects approximately 1 in 5,000 people. It is caused by a defect in connective tissue, the material that supports and holds together cells, organs, and tissues throughout the body. Because of this widespread role, Marfan syndrome can affect multiple organ systems, with features …

Sequencing-based genetic tests have uncovered a vast array of BRCA2 variants. The number of observed variants continues to increase due to expanding therapeutic options and improved sampling. With rapid advances in high-throughput molecular and bioinformatic pipelines for sequencing, the bottleneck in genetic testing has shifted to the clinical interpretation of …

Unlike adult cancers, childhood cancers are not caused by aging or environmental factors, but arises from malfunctions in developmental biology. One example is neuroblastoma, which originates from precursor cells of the sympathetic nervous system. Depending on the developmental stage at which the cancer cells occur, different neuroblastoma subtypes can emerge. …

Ovarian carcinosarcoma is a rare and aggressive type of ovarian cancer with a poor prognosis and very few treatment options to date. Most patients do not respond well to standard chemotherapy, which makes the search for new therapies urgent. This research investigates if specific enzymes (L-asparaginases), already used in the …

T-cell acute lymphoblastic leukemia (T-ALL) is a rare but aggressive blood cancer that affects both children and adults. While advances in current treatment regimens have significantly improved survival rates in pediatric patients, outcomes for adults remain poor, largely due to treatment-related toxicities and lower tolerance to intensive therapy. Patients who …