Inflammatory Bowel Disease (IBD) includes Crohn’s disease and ulcerative colitis (UC), which cause severe inflammation in the gastro-intestinal tract. Symptoms including rectal bleeding, weight loss, and abdominal pain significantly impact patient well-being, leading to stress, anxiety, depression, and can result in severe complications such as infections, cancer, and eventually death. …

This study focusses on using new machine learning approaches to study cell contents at different levels, called omics. Evaluating tissue specific patterns of different omics and the relation between the different levels, could hold significant promise in several sectors. Understanding how various omics work together to create tissue specific functions, …

The global prevalence of overweight individuals has reached a staggering 2.5 billion, of which 890 million are classified as having obesity, putting them at risk of severe health complications such as type 2 diabetes, cardiovascular diseases and cancer. The obesity epidemic poses a pressing public health concern, contributing to increased …

Cardiovascular diseases (CVDs) have high morbidity and mortality rates worldwide. Acute myocardial infarction (MI) is one of the CVDs that occurs when a blood clot obstructs the arteries. Patients who have suffered from an MI frequently have heart failure, which can lead to death. It also greatly affects the quality …

Introduction - Soft tissue sarcomas (STS) are rare malignant tumors arising from connective tissues. They have more than 70 subtypes and very few of them are therapeutically targeted. Hardly any drug trials for potential drug therapies are succeeding because in vitro models fail to represent their effects in a precisely …

Diabetic peripheral neuropathy (DPN) arises from diabetes-induced nerve damage, primarily impacting peripheral nerves. This damage often leads to symptoms such as numbness, tingling, and pain in the lower extremities. Additionally, it affects muscles, causing muscle weakness, loss, and alterations in muscle fiber type composition. By examining these changes, researchers can …

The paediatric chronic kidney disease (CKD) zebrafish models that will be generated based on initial results from this project can be used to better understand the pathophysiology of the disease and perform high-throughput drug screens to identify compounds that can ameliorate the phenotype of the disease. This can lead to …

Layman summary with societal impact The revised criteria for diagnosing patients with NF1 emphasize the importance of genetic variant detection. This research focuses on optimizing current techniques to efficiently and precisely identify variants in potential NF1 patients, which could be a very helpful tool in diagnosis. The ability to detect …

With this research, the fields of proteomics and bioinformatics could be significantly advanced through improved data pre-processing, leading to enhanced LC-MS data quality. By effectively calibrating proteomics data, this study enables more accurate peptide and protein identification, as well as improved post-translational modification (PTM) analysis. Enhanced PTM identification rates could …

This study focuses on rather fundamental research concepts and is therefore further removed from a direct societal impact than translational research. However, this study aims to provide insights into how we can analyse metaproteomic samples with more certainty and accuracy. This is vital if we want to gather truthful and …