COMMUNITY OUTREACH 1) POPULARIZING SUMMARY High-grade gliomas are some of the most aggressive brain tumors, growing quickly and spreading into surrounding brain tissue. These characteristics make them particularly difficult to treat with the current methods of cancer treatment like surgery, chemotherapy, or radiation. Because of this, patients with these tumors have a poor prognosis. This study focuses on understanding how these tumor cells migrate to other areas of the brain and which factors are involved in that process, in order to create a therapy that uses these migration tactics to its advantage. Based on these insights, this thesis explored a new concept called motility trapping. This technique uses signals (mostly chemical or electrical) to guide tumor cells that have migrated to other areas of the brain to a specific location, where they can be more easily treated, in the hope to cure this decease. This strategy could enhance the precision of treatment, reducing the risk to healthy brain tissue and potentially lowering side effects. The findings from this research may lead to targeted therapies that address the unique challenges of treating high-grade gliomas, with the potential to improve outcomes for patients facing this complex disease. 2) SOCIETAL VALUE AND IMPACT This study offers knowledge to aid the development of a promising new technique that, if successful, could provide a curative therapy for these tumors that are incurable to this day. Furthermore, the therapies discussed in this thesis could reduce the harmful side effects of traditional therapies, enhancing patient outcomes and quality of life, which could prove to be a major benefit for patients. If this therapy is successful, it could mean an incredible impact on the healthcare system, as it would reduce reliance on high-dose systemic therapies. This would result in lower treatment costs and improve healthcare resource allocation. Finally, understanding tumor migration at a deeper level may open doors for further research and innovation, not only for gliomas but also for other invasive cancers. This technique represents a valuable step toward refining brain cancer treatment strategies and expanding options for patients and healthcare providers alike.