Graves’ disease is a thyroid disorder, which can lead to symptoms in different organ systems, such as the skin and the eyes. When the eyes are affected, we call it Graves’ orbitopathy, this is an autoimmune disease which can lead to the loss of eyesight and changes in facial features. Given the severity of the symptoms, patients often suffer from a psychological impact as well. To reduce the burden for patients, it is important to find a way to diagnose them earlier in the process of this disease. A fast diagnosis is helpful in order to treat patients more quickly, thus preventing the development of (severe) symptoms. Furthermore, quick treatment with medication prevents the necessity of severe surgical procedures. In the blood of patients there are some proteins and pieces of genetic material present, which can help us to determine which patients with the thyroid disorder are at risk for developing eye symptoms. On a societal level, this research is important in order to determine new methods for identifying patients at risk. However, the underlying mechanisms are not fully understood yet, which implies a shortage of knowledge and research about this topic. With this dissertation we aimed to give an overview of several proteins and pieces of genetic material that have been studied already and could serve as identifiers for patients at risk. Although, these need to be investigated more in-depth as well. The identification of patients at risk is useful for both individual patients and for healthcare systems.