Teeth play an important role in our daily lives, helping us chew food and speak clearly. If they are not taken care of properly, problems such as cavities and gum disease can develop. These problems not only have a huge impact on the quality of live but also place a massive financial burden on society. According to the WHO , dental caries is the most common oral disease in the world, with an estimated 2.5 billion people being affected each year. Nowadays, dentist repair the damaged or infected teeth with the use of surgery (removal and implants) or fillings (to close the cavities), but these artificial materials aren’t perfect. Over time, fillings can wear out, and implants might get loose or even be rejected by the body. That is why scientist are looking into different ways to repair teeth. By studying the natural tooth formation with the use of dental follicle stem cells (which are cells found in the tissue surrounding the unerupted wisdom teeth). These stem cells can be grown in Matrigel, a cell supportive structure, allowing them to form organoids (3D-tissue structures). These organoids can be studied and differentiated to ameloblast cells, the cells that form the most outer layer of the tooth (enamel), to look more into regenerative repair methods. While this research is still in progress, it could completely change the way we treat enamel-related problems in the future, making repairs more natural and long-lasting.