PART A: The Importance of an Integrated Approach in Combating Bioterrorism This review provides an insight into the phases of the emergency response cycle and emphasizes the importance of an integrated and proactive approach in combating bioterrorism. By gaining a better understanding of these procedures, policymakers and health care workers can react more effectively to bioterrorist threats and minimize their impact. PART B: Symptom-Based Overview and Treatment of Diseases Caused by Bioterrorism Agents The second part of this review aims to provide a comprehensive overview of symptoms stemming from diseases caused by bioterrorism agents, followed by initiating targeted treatment without the necessity of tests to directly identify the specific pathogen. The ultimate goal is to create a flowchart for emergency and primary care providers, outlining the initial alarm symptoms followed by empirical treatment and the measures they can take before determining the pathogen they are dealing with.