Pregnancy complications continue to be a huge burden on prenatal healthcare systems and pregnant women and their fetuses. Today, there is still a lack of accurate screening methods to predict pregnancy complications, such as preeclampsia, early on in pregnancy. Advancements in prenatal screening methods can provide significant benefits to pregnant women, fetuses, and healthcare professionals such as gynaecologists, midwives, and nurses. Early detection of high-risk pregnancies before the onset of symptoms could potentially limit the risk of adverse outcomes for both mother and child, thereby strongly reducing the mortality rates. Lowering such adverse outcomes will also lead to a decrease in the costs associated with neonatal or maternal intensive care and long-term medical treatment, which can be substantial. More accurate screening will not only enable improved healthcare provision with more intensive monitoring and closer follow-up of both mother and fetus throughout gestation, but can also reduce overdiagnosis and unnecessary hospitalizations, treatment, and follow-up consultations, resulting in significant cost savings. When at-risk pregnancies are identified early on in the pregnancy, possible preventive measures can be taken to prevent or delay the onset of complications. This dissertation project could potentially aid in the need to more accurately predict future pregnancy complications during the first trimester, and hence provide proper follow-up and treatment. Furthermore, the improvement in prenatal care is expected to reduce the emotional and financial burden on both families and healthcare systems.