The paediatric chronic kidney disease (CKD) zebrafish models that will be generated based on initial results from this project can be used to better understand the pathophysiology of the disease and perform high-throughput drug screens to identify compounds that can ameliorate the phenotype of the disease. This can lead to the discovery of more cost-effective treatment options that will decrease the need for renal replacement therapies (RRT) such as kidney transplantation and dialysis. Dialysis affects the patient’s physical health, causing stress, anxiety and depression, reducing the possibility for social interaction and disrupting work or education for the patient. Additionally, it affects overall family dynamics, disrupting family life, straining relationships and causing emotional stress. Therefore, the reduced need for dialysis will result in an overall increased quality of life for both the patients and their family members. It will also reduce the burden of kidney disease on the healthcare system. The dialysis costs, which in Belgium are completely covered by the public health insurance, range from €80,000 to €120,000 per patient per year. Reducing the number of patients requiring dialysis would free up government budgets for other societal purposes.