The global prevalence of overweight individuals has reached a staggering 2.5 billion, of which 890 million are classified as having obesity, putting them at risk of severe health complications such as type 2 diabetes, cardiovascular diseases and cancer. The obesity epidemic poses a pressing public health concern, contributing to increased rates of sickness, premature death, and rising healthcare costs. Gastric bypass surgery (GBS) offers hope for those struggling with severe obesity. It involves making the stomach smaller and changing the way food travels through the intestine, resulting in significant weight loss. However, it is unclear how this weight loss affects the way the thyroid gland operates in obese individuals. Research findings on this topic are mixed, hence, further research is needed to explore the relationship between bariatric surgery and thyroid hormone (TH) metabolism. By investigating the impact of GBS-induced weight loss on THs we aim to better understand the connection between obesity, thyroid function and the metabolic effects of bariatric surgery. Research into these relationships could potentially contribute to advancements in treatments for obesity and related health issues and help reduce the burden of obesity-related diseases on society. While this study may not single-handedly resolve obesity, it may offer valuable insights to stimulate further research or pave the way for future developments in addressing this complex health challenge.