Mental health is a state of well-being that enables humans to cope with distorting factors and lets us function on a day-to-day basis. Rightfully so, mental health has been getting more attention than ever before. Bad mental health can lead to underperforming, physical impairment, and can lead to detrimental consequences like suicide. Our mental health is influenced by a plethora of factors but can be significantly affected by major events. The COVID-19 pandemic not only caused millions of deaths worldwide, stripped people from their sense of smell, or made people generally ill, it also affected people’s mental health in a major way. Lockdowns, isolation, and grief are examples how the pandemic negatively influenced the mental health of people all around the globe. A group hit specifically hard by the pandemic are general practitioners (GPs). GPs played a crucial role in primary care when handling the pandemic, but their heroic efforts came at a price. Overworking, loss of patients, and fear for their own safety among others, negatively affected the mental health of GPs at a time where optimal performance was crucial. Several studies have attempted to grasp how big the mental impact of the COVID-19 pandemic was on GPs. Varying rates have been reported when it came to major mental health outcomes like anxiety, depression, stress, PTSD, burn-out, sleeping difficulty and so on. This study hopes to add valuable information to already existing literature, whilst also providing new insights. It will be comparing the first two waves in Flanders, Belgium to find if any of the mental health outcomes are more prevalent at a certain point during the pandemic. This master’s thesis also provides a clear introduction to COVID-19, consisting of a timeline, what the virus looks like, how it infects people, and what we can do to combat it. Literature around COVID-19 is vast, so our introduction attempts to cover all important topics without going to much into detail. Depending on the region and time, the course of the pandemic variated, hence why existing literature sometimes varies greatly. Our study took place in Flanders, Belgium, a place that has not been independently researched on this topic, at a time where the main pandemic has already passed. This allows our study to compare mental health outcomes before, during, and after the pandemic. This master’s thesis adds value by not only providing new insights, but also by expanding already existing insights in a different region and a different time. In case of future health emergencies, our research could be used to better protect GPs from negative mental health effects by providing tailored prevention, targeted interventions, and clear guidelines.